Tumour Cell Heterogeneity [version 1; referees: 5 approved]
نویسندگان
چکیده
The population of cells that make up a cancer are manifestly heterogeneous at the genetic, epigenetic, and phenotypic levels. In this mini-review, we summarise the extent of intra-tumour heterogeneity (ITH) across human malignancies, review the mechanisms that are responsible for generating and maintaining ITH, and discuss the ramifications and opportunities that ITH presents for cancer prognostication and treatment. This article is included in the F1000 Faculty channel. Reviews Referee Status:
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